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Alzheimer’s Disease and Related Disorders Treatment and Outcomes in America: Changing Policies and Systems [Administrative Supplement]

Project status
Vincent Mor, Elizabeth White
Institution web page
Host institution
Brown University School of Public Health, Center for Gerontology and Healthcare Research Genesis HealthCare
Team members
Brown University: Vincent Mor (PI), Elizabeth White, Stefan Gravenstein, Cyrus Kosar, Orestis Panagiotou, Kevin McConeghy, Jeffrey Hiris, Yoojin Lee, Christopher Santostefano, Xiaofei Yang Genesis HealthCare: Richard Feifer, Carolyn Blackman, Richard Castor, Clifford Boyd, Denine Hastings
Funding information (if funded)
National Institute on Aging, 3P01AG027296-11S1
Project Summary

The objective of this administrative supplement is to examine the impact of COVID-19 in US nursing homes, understand its treatment and outcomes in this setting, and identify organizational characteristics that may mitigate or fuel spread of the infection among staff and residents. This is a collaborative partnership between Genesis HealthCare, the largest long-term care provider in the US, and Brown University. To date, we have examined facility and county predictors of outbreak, individual patient risk factors for mortality and other outcomes, mortality trends, symptom presentation, prevalence of asymptomatic and pre-symptomatic infection, and SARS-CoV-2 antibody development in this population. Other analyses are currently underway focused on post-acute care, functional recovery, sensitivity and specificity of SARS-CoV-2 antigen tests, medication management, and COVID-19 outcomes among individuals with chronic kidney disease.


Outputs / Expected Outputs

Several papers already published, others under review and in development for publication in late 2020-mid 2021:

White, E.M., Kosar, C.M., Feifer, R.A., Blackman, C., Gravenstein, S., Ouslander, J., & Mor, V. Variation in SARS-CoV-2 Prevalence in US Skilled Nursing Facilities. J Am Geriatr Soc. 2020; 68(10): 2167-2173. DOI: 10.1111/jgs.16752

White, E.M., Santostefano, C.M., Feifer, R.A., Kosar, C.M., Blackman, C., Gravenstein, S. & Mor, V. Asymptomatic and pre-symptomatic SARS-CoV-2 infection rates in a multistate sample of skilled nursing facilities. JAMA Intern Med. 2020 Oct. [Advanced online publication]. DOI: 10.1001/jamainternmed.2020.5664

Blackman, C., Farber, S., Feifer, R.A., Mor, V., & White, E.M. An Illustration of SARS-CoV-2 Dissemination Within a Skilled Nursing Facility Using Heat Maps. J Am Geriatr Soc. 2020; 68(10): 2174-2178. DOI: 10.1111/jgs.16642

McConeghy, K.W., White, E.M., Panagiotou, O.A., Santostefano, C.M., Halladay, C., Feifer, R.A., Blackman, C., Rudolph, J.L., Mor, V. & Gravenstein, S. (2020). Temperature Screening for SARS?CoV?2 in Nursing Homes: Evidence from Two National Cohorts. J Am Geriatr Soc. 2020. [Advanced online publication]. DOI: 10.1111/jgs.16876

Panagiotou, O.A., Kosar, C.M., White, E.M., Santostefano, C.M., Feifer, R.A., Blackman, C., Rudolph, J.L., Gravenstein, S., Mor, V. Risk Factors Associated with All-Cause 30-Day Mortality in Nursing Home Residents with COVID-19. JAMA Intern Med. 2020. [In press]


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Alzheimer’s Disease and Related Disorders Treatment and Outcomes in America: Changing Policies and Systems [Administrative Supplement]