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Alzheimer’s Disease and Related Disorders Treatment and Outcomes in America: Changing Policies and Systems [Administrative Supplement]

Project status
Vincent Mor, Elizabeth White
Institution web page
Host institution
Brown University School of Public Health, Center for Gerontology and Healthcare Research Genesis HealthCare
Team members
Brown University: Vincent Mor (PI), Elizabeth White, Stefan Gravenstein, Cyrus Kosar, Orestis Panagiotou, Kevin McConeghy, Jeffrey Hiris, Yoojin Lee, Christopher Santostefano, Xiaofei Yang Genesis HealthCare: Richard Feifer, Carolyn Blackman, Richard Castor, Clifford Boyd, Denine Hastings
Funding information (if funded)
National Institute on Aging, 3P01AG027296-11S1
Project Summary

The objective of this administrative supplement is to examine the impact of COVID-19 in US nursing homes, understand its treatment and outcomes in this setting, and identify organizational characteristics that may mitigate or fuel spread of the infection among staff and residents. This is a collaborative partnership between Genesis HealthCare, the largest long-term care provider in the US, and Brown University. To date, we have examined facility and county predictors of outbreak, individual patient risk factors for mortality and other outcomes, mortality trends, symptom presentation, prevalence of asymptomatic and pre-symptomatic infection, and SARS-CoV-2 antibody development in this population. Other analyses are currently underway focused on post-acute care, functional recovery, sensitivity and specificity of SARS-CoV-2 antigen tests, medication management, and COVID-19 outcomes among individuals with chronic kidney disease.


Outputs / Expected Outputs
Several papers associated with the project have been published:

An Illustration of SARS-CoV-2 Dissemination Within a Skilled Nursing Facility Using Heat Maps.

Variation in SARS-CoV-2 Prevalence in U.S. Skilled Nursing Facilities

Temperature Screening for SARS?CoV?2 in Nursing Homes: Evidence from Two National Cohorts.

Asymptomatic and pre-symptomatic SARS-CoV-2 infection rates in a multistate sample of skilled nursing facilities.

Risk factors associated with all-cause 30-day mortality in nursing home residents with COVID-19.

SARS-CoV-2 Antibody Detection in Skilled Nursing Facility Residents.

COVID-19 Mortality Rates Among Nursing Home Residents Declined From March To November 2020.

Short Term Impact of Nursing Home SARS-CoV-2 Vaccinations on New Infections, Hospitalizations and Deaths.

Incident SARS-CoV-2 Infections Among mRNA-Vaccinated and Unvaccinated Nursing Home Residents.

Adverse events following mRNA SARS-CoV-2 vaccination among U.S. nursing home residents.

COVID-19 Vaccine Acceptance Among Black and Hispanic Nursing Home Staff: Building Trust to Protect Both Staff & Residents.

Accuracy of ICD-10 codes for identifying skilled nursing facility residents with lab-confirmed COVID-19.

A systematic review of long-term care facility characteristics associated with COVID-19 outcomes.

Association of Kidney Function With 30-Day Mortality Following SARS-CoV-2 Infection in Nursing Home Residents: A Retrospective Cohort Study

Adverse Events Following One Dose of mRNA COVID-19 Vaccination among U.S. Nursing Home Residents with and without a previous SARS-CoV-2 Infection.

Lessons for deprescribing from a nonessential medication hold policy in US nursing homes.


Care setting
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Alzheimer’s Disease and Related Disorders Treatment and Outcomes in America: Changing Policies and Systems [Administrative Supplement]